Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages
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چکیده
منابع مشابه
Reciprocal Supportive Interplay between Glioblastoma and Tumor-Associated Macrophages
Glioblastoma multiforme (GBM) is the most lethal and aggressive type of primary brain malignancy. Failures of the traditional therapies in treating GBMs raise the urgent requirement to develop new approaches with more responsive targets. The phenomenon of the high infiltration of tumor-associated macrophages (TAMs) into GBMs has been observed for a long time. Regardless of the limited knowledge...
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Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis. In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...
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Glioblastoma is one of the most common brain tumors in adults with poor prognosis, aggressiveness, and treatment resistance. Vasculogenic mimicry (VM) consists of generating vascular-like channels by tumor cells, independent of endothelial angiogenesis. Studies showed in glioblastoma, the proportion of VM to all vascular channels is associated with poor prognosis and higher invasiveness levels....
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PURPOSE CD44 is of functional importance for tumor initiation and progression in colorectal cancer, but how this molecule benefits cancer cells from the tumor microenvironment, especially tumor-associated macrophages (TAM), remains poorly defined. EXPERIMENTAL DESIGN In vivo tumorigenic assays were conducted to assess the role of murine TAMs in the tumorigenesis of human colorectal cancer cel...
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vi Chapter 1: Introduction 1 Chapter 1 References 18 Chapter 2: Hitting Them Where They Live: Targeting the Glioblastoma Perivascular Stem Cell Niche 24 Chapter 2 References 42 Chapter 3: Methods of Transcriptional Analysis 50 Chapter 3 References 67 Chapter 4: Discovery of PDE7B as a novel effector of GBM growth by computational deconvolution of an in vitro physical 71 coculture system. Chapte...
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ژورنال
عنوان ژورنال: Cancers
سال: 2014
ISSN: 2072-6694
DOI: 10.3390/cancers6020723